Uroplakin 1A (Urothelial Differentiation Marker)

• Gene Name:

  [UPK1A]

• NCBI Gene ID:

  11045

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.

• Other Gene Names:

  [UPK1A; UPK1A; UP1A; UPIA; UPKA; TSPAN21; TSPAN21; UP1a; Tspan-21; UPIa; UPKa]

• Short Name:

  [Uroplakin 1A]

• Other Product Names:

  [uroplakin-1a isoform 2; Uroplakin-1a; uroplakin-1a; uroplakin 1A; Tetraspanin-21; Tspan-21; Uroplakin Ia]

• NCBI GI Number:

  527498307

• NCBI Accession Number:

  NP_001268372.1

• NCBI GB Accession Number:

  NP_001268372.1

• Uniprot Accession Number:

  O00322