MerTK (Innate Immune Checkpoint)

MerTK (Innate Immune Checkpoint)

• Gene Name: [MERTK]
• NCBI Gene ID: 10461
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8°C.
  Antibody without azide: store at -20 to -80°C.
  Non-hazardous. No MSDS required.
• Specificity: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
• Other Gene Names: [MERTK; MERTK; MER; RP38; c-Eyk; c-mer; Tyro12; MER]
• Short Name: [MerTK]
• Other Product Names: [tyrosine-protein kinase Mer; Tyrosine-protein kinase Mer; tyrosine-protein kinase Mer; MER proto-oncogene, tyrosine kinase; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK]
• NCBI GI Number: 66932918
• NCBI Accession Number: NP_006334.2
• NCBI GB Accession Number: NP_006334.2
• Uniprot Accession Number: Q12866