MerTK (Innate Immune Checkpoint)

• Gene Name:

  [MERTK]

• NCBI Gene ID:

  10461

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8°C.
  Antibody without azide: store at -20 to -80°C.
  Non-hazardous. No MSDS required.

• Specificity:

  MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

• Other Gene Names:

  [MERTK; MERTK; MER; RP38; c-Eyk; c-mer; Tyro12; MER]

• Short Name:

  [MerTK]

• Other Product Names:

  [tyrosine-protein kinase Mer; Tyrosine-protein kinase Mer; tyrosine-protein kinase Mer; MER proto-oncogene, tyrosine kinase; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK]

• NCBI GI Number:

  66932918

• NCBI Accession Number:

  NP_006334.2

• NCBI GB Accession Number:

  NP_006334.2

• Uniprot Accession Number:

  Q12866