CD163 (Monocyte & Macrophage Marker)

CD163 (Monocyte & Macrophage Marker)

• Gene Name: [CD163]
• NCBI Gene ID: 9332
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8°C. Non-hazardous. No MSDS required.
• Specificity: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.
• Other Gene Names: [CD163; CD163; M130; MM130; SCARI1; M130; sCD163]
• Short Name: [CD163]
• Other Product Names: [scavenger receptor cysteine-rich type 1 protein M130 isoform a; Scavenger receptor cysteine-rich type 1 protein M130; scavenger receptor cysteine-rich type 1 protein M130; CD163 molecule; Hemoglobin scavenger receptor; CD_antigen: CD163]
• NCBI GI Number: 344179110
• NCBI Accession Number: NP_004235.4
• NCBI GB Accession Number: NM_004244.5
• Uniprot Accession Number: Q86VB7