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E-Cadherin/CD324 (Intercellular Junction Marker)

CAT:
544-MBS4380381-01
Size:
0.02 mg (With BSA & Azide at 0.2mg/mL)
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
E-Cadherin/CD324 (Intercellular Junction Marker) - image 1

E-Cadherin/CD324 (Intercellular Junction Marker)

  • Gene Name: [CD324]
  • NCBI Gene ID: 999
  • Reactivity: Human. Others not known
  • Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
    Antibody without azide - store at -20 to -80 degree C.
    Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Specificity: Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help of mesothelioma.
  • Other Gene Names: [CDH1; CDHE; UVO; E-cadherin]
  • Short Name: [E-Cadherin/CD324]
  • Other Product Names: [cadherin-1 isoform 2; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin]
  • NCBI GI Number: 953768348
  • NCBI Accession Number: NP_001304113.1
  • NCBI GB Accession Number: NM_001317184.1
  • Uniprot Accession Number: P12830