3'-Hydroxy Repaglinide

• UNSPSC Description:

  3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2].

• Target Antigen:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/3-hydroxy-repaglinide.html

• Smiles:

  O=C(O)C1=CC=C(CC(NC(C2=CC=CC=C2N3CC(O)CCC3)CC(C)C)=O)C=C1OCC

• Molecular Weight:

  468.59

• References & Citations:

  [1]A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probedrugs and their corresponding metabolites in human serum and urine. Anal Bioanal Chem. 2017 Jan;409(1):251-268.|[2]Honkalammi J, et al. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther. 2011 Apr;89(4):579-86.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  874908-14-2