PARP-1 rabbit pAb
CAT:
855-ES14255-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PARP-1 rabbit pAb
- Description: This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],
- Synonyms: Poly [ADP-ribose] polymerase 1 (PARP-1;EC 2.4.2.30;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD(+) ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1)
- Gene ID: 142
- UniProt: P09874
- Cellular Locus: Nucleus. Nucleus, nucleolus. Chromosome. Localizes to sites of DNA damage..
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthesized peptide derived from human PARP-1
- Clonality: Polyclonal
- Validated Applications: IHC, IF, WB
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: IHC-p 1:50-200, WB 1:500-2000
- Molecular Weight: 113kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.