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Fitusiran

CAT: 0804-HY-132587-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132587-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia[1].
CAS Number
1499251-18-1
Product Name Alternative
ALN-AT3SC; SAR439774
UNSPSC
12352208
Target
Factor Xa; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fitusiran.html
Purity
94.74
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Fitusiran]
Molecular Formula
C520H679F21N175O309P43S6
Molecular Weight
16248.2 (AS: 7675 + SS: 8573.2)
References & Citations
[1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19 (6) :1436-1446.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched

Alternative Products

CatalogName
T38986-01Fitusiran
T74877-01GalNAc unconjugated/naked Fitusiran

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