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Bromhexine (hydrochloride)

CAT: 0804-HY-B0372A-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0372A-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].
CAS Number
611-75-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HIV; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Autophagy
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Bromhexine-hydrochloride.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)
Smiles
CN(C1CCCCC1)CC2=CC(Br)=CC(Br)=C2N.Cl
Molecular Formula
C14H21Br2ClN2
Molecular Weight
412.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Jared M Lucas, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014 Nov;4 (11) :1310-25.|[2]Li Wen Shen, et al. TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. Biochimie. 2017 Nov;142:1-10.|[3]Roberto Maggio, et al. Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. Pharmacol Res. 2020 Jul;157:104837.|[4]Santosh Chauhan, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015 Oct 27;6:8620.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1

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