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MLS1547

CAT: 0804-HY-128121-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128121-01Size:5 mg
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Description
MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM) . MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay) . MLS1547 acts as an antagonist for dopamine (DA) -stimulated β-arrestin recruitment to the D2R (IC50=9.9 μM) [1][2].
CAS Number
315698-36-3
UNSPSC
12352005
Hazard Statement
H301
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mls1547.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3
Molecular Formula
C19H19ClN4O
Molecular Weight
354.83
Precautions
H301
References & Citations
[1]Free RB, et al. Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014;86 (1) :96-105.|[2]Chun LS, et al. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor. Front Synaptic Neurosci. 2018;10:2. Published 2018 Feb 21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor

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CatalogName
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