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MLS1547

CAT: 0013-GTR19171628-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171628-01Size:50 mg
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Description
MLS1547 is a potent and selective G protein-biased agonist of the dopamine D2 receptor, exhibiting a Ki of 1.2 μM. It activates G protein-mediated signaling with an EC50 of 0.37 μM in calcium flux assays, making it a valuable research tool for studying biased signaling in neuropharmacology, including in vitro models of psychiatric and neurological disorders.
CAS Number
315698-36-3
Product Name Alternative
MLS1547, MLS-1547, MLS 1547, MLS 000051547, MLS000051547, MLS-000051547, Inhibitor, inhibit, biased, Dopamine Receptor, DopamineReceptor, D2 receptor, protein, recruitment, signaling, β-arrestin
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.02% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.82 mM) ; DMSO:45 mg/mL (126.82 mM)
Smiles
Oc1c (CN2CCN (CC2) c2ccccn2) cc (Cl) c2cccnc12
Molecular Formula
C19H19ClN4O
Molecular Weight
354.83
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mls1547
CAS Number315698-36-3
PubChem CID1093278
IUPAC Name5-chloro-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol
Molecular FormulaC19H19ClN4O
Molecular Weight354.8
XLogP3.2
Topological Polar Surface Area52.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity432
SMILES
C1CN(CCN1CC2=CC(=C3C=CC=NC3=C2O)Cl)C4=CC=CC=N4
InChI
InChI=1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
InChIKey
OPEJNANYABTIGC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mls1547
CAS: 315698-36-3
CID: 1093278
Formula: C19H19ClN4O
MW: 354.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.8
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass354.1247389
Monoisotopic Mass354.1247389
Topological Polar Surface Area52.5 Ų
Heavy Atom Count25
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T28073-01MLS1547

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