AS-183

• Description :

  AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM) . AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ​​of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].

• CAS Number :

  [147317-12-2]

• UNSPSC :

  12352005

• Target :

  Acyltransferase

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/as-183.html

• Smiles :

  O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C

• Molecular Formula :

  C19H34O3

• Molecular Weight :

  310.47

• References & Citations :

  [1]Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993) : 1196-1202.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported