AS-183

• UNSPSC Description:

  AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ​​of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].

• Target Antigen:

  Acyltransferase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/as-183.html

• Smiles:

  O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C

• Molecular Weight:

  310.47

• References & Citations:

  [1]Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993): 1196-1202.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  147317-12-2