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AS-183

CAT: 0804-HY-129340Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129340Size:1 Each
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Description
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM) . AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ​​of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].
CAS Number
147317-12-2
UNSPSC
12352005
Target
Acyltransferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/as-183.html
Smiles
O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
Molecular Formula
C19H34O3
Molecular Weight
310.47
References & Citations
[1]Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993) : 1196-1202.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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