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Withanolide A (Standard)

CAT: 0804-HY-N7028RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N7028RSize:1 Each
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Description
Withanolide A (Standard) is the analytical standard of Withanolide A. This product is intended for research and analytical applications. Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases[1][2][3][4].
CAS Number
32911-62-9
UNSPSC
12352005
Target
Apoptosis; Notch; Reference Standards
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/withanolide-a-standard.html
Smiles
O=C1O[C@@]([H])([C@@](C)([C@H]2CC[C@]3([C@@]4([C@H]5[C@@H]([C@@](O)(CC=CC6=O)[C@]6([C@]4(CC[C@@]32C)[H])C)O5)[H])[H])O)CC(C)=C1C
Molecular Formula
C28H38O6
Molecular Weight
470.60
References & Citations
[1]Kuboyama T, et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144 (7) :961-71..|[2]Zhang X, et al. Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecol Oncol. 2012 Mar;124 (3) :606-12.|[3]Pathak P, et al. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation. J Ethnopharmacol. 2021 Oct 5;278:114296.|[4]Baitharu I, et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014 Oct 13;9 (10) :e105311.|[5]Kuboyama T, et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144 (7) :961-71..|[6]Zhang X, et al. Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecol Oncol. 2012 Mar;124 (3) :606-12.|[7]Pathak P, et al. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation. J Ethnopharmacol. 2021 Oct 5;278:114296.|[8]Baitharu I, et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014 Oct 13;9 (10) :e105311.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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