Isonicotinic acid

• Description:

  Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H319

• Target:

  Drug Intermediate; Drug Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/isonicotinic-acid.html

• Concentration:

  10mM

• Purity:

  99.96

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(O)C1=CC=NC=C1

• Molecular Formula:

  C6H5NO2

• Molecular Weight:

  123.11

• Precautions:

  H319

• References & Citations:

  [1]Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59 (11) :6791-9.|[2]Boltz D, et al. Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells. Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618811416.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [55-22-1]