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Triapine (hydrochloride)

CAT: 0804-HY-10082BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10082BSize:1 Each
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Description
Triapine (hydrochloride) is the hydrochloride form of Triapine. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer[1].
CAS Number
216240-62-9
Product Name Alternative
3-AP (hydrochloride) ; PAN-811 (hydrochloride) ; OCX191 (hydrochloride)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/triapine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
S=C(N)N/N=C/C1=NC=CC=C1N.[H]Cl
Molecular Formula
C7H10ClN5S
Molecular Weight
231.71
References & Citations
[1]Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84 (4) :e475-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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