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LRRK2 Antibody (HRP)

CAT: 0013-GTR18029036Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029036Size:100 µg
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Description
Mouse monoclonal to LRRK2 (HRP) . LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features..
Product Name Alternative
LRRK2, Leucine-rich repeat kinase 2, Leucine-rich repeat serine/threonine-protein kinase 2, RIP7, RIPK7, PARK8, Dardarin, ROCO 2, Augmented in rheumatoid arthritis 17
UniProt
Q5S007
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein, amino acids 1-500 (N-terminus) of human LRRK2. 83% identical in mouse and rat. No significant identity with LRRK1.
Target
LRRK2
Clonality
Monoclonal
Clone
N138/6 (Formerly sold as S138-6)
Conjugation
HRP
Field of Research
Cell Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
200kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_940980
Host or Source
Mouse
Preservative
73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
Isotype
IgG1
Entrez
120892

UniProtKB · Q5S007

Leucine-rich repeat serine/threonine-protein kinase 2

LRRK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5S007
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRRK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1, 3.6.5.-
Processing
—
Secondary accessions
A6NJU2, Q6ZS50, Q8NCX9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingGTP-bindingNucleotide-binding

Biological process

AutophagyDifferentiation

Cellular component

Cell projectionCytoplasmCytoplasmic vesicleCytoskeletonEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneMitochondrionMitochondrion outer membraneSynapse

Domain

Coiled coilLeucine-rich repeatRepeatWD repeat

Disease

Disease variantNeurodegenerationParkinson diseaseParkinsonism

Molecular function

GTPase activationHydrolaseKinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

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