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LRRK2 Antibody (APC)

CAT: 0013-GTR18029026Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029026Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to LRRK2 (APC) . LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features..
Product Name Alternative
LRRK2, Leucine-rich repeat kinase 2, Leucine-rich repeat serine/threonine-protein kinase 2, RIP7, RIPK7, PARK8, Dardarin, ROCO 2, Augmented in rheumatoid arthritis 17
UniProt
Q5S007
Reactivity
Human, Rat
Immunogen
Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. < 30% identity with LRRK1.
Target
LRRK2
Clonality
Monoclonal
Clone
N231B/34 (Formerly sold as S231B-34)
Conjugation
APC
Field of Research
Cell Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:100)
Molecular Weight
200kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
10 μg/ml was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_940980
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2a
Entrez
120892

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