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SUR2A Antibody (FITC)

CAT: 0013-GTR18028981Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028981Size:100 µg
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Description
Mouse monoclonal to SUR2A (FITC) . Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6. x (6. 1 and 6. 2) . The association of four K ir6. x and four SUR subunits form an ion conducting channel commonly referred to as the K ATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir 6. x potassium channel. Hence the K ATP channel monitors the energy balance within the cell..
Product Name Alternative
ABCC9, Sulfonylurea receptor 2, CMD10, ABC37, ATP-binding cassette transporter sub-family C member 9, Sulfonylurea receptor 2A, isoform SUR2A
UniProt
P70170
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A
Target
SUR2A
Clonality
Monoclonal
Clone
N319A/14 (Formerly sold as S319A-14)
Conjugation
FITC
Field of Research
Cancer Biology, Cell Biology, Disease Biomarkers, Neuroscience, Signal Transduction
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
120kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of SUR2A in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_001038185.1
Host or Source
Mouse
Preservative
640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
Isotype
IgG2A
Entrez
20928

UniProtKB · P70170

ATP-binding cassette sub-family C member 9

ABCC9_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P70170
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Abcc9
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O08902, O08920, P70171
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Technical term

Direct protein sequencingReference proteome

PTM

Glycoprotein

Cellular component

Membrane

Molecular function

Receptor

Domain

RepeatTransmembraneTransmembrane helix

Biological process

Transport

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