Products for Research Use Only
RegisterLogin

Notch1 Antibody (APC)

CAT: 0013-GTR18028972Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18028972Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Mouse monoclonal to Notch1 (APC) . Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N (TM) and a N-terminal fragment N (EC) . Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane..
Product Name Alternative
Neurogenic locus notch homolog protein 1, hN1, Translocation associated notch protein, TAN1, TAN-1, Motch A, mT14, p300, Motch, Mis6, Neurogenic locus notch protein homolog, NICD, Notch 1 intracellular domain, Notch gene homolog 1 (Drosophila), Notch homolog 1, translocation-associated (Drosophila), NOTCH Drosophila, homolog of 1, Translocation associated notch homolog, Translocation associated notch protein TAN 1, xotch
UniProt
Q01705
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1
Target
Notch1
Clonality
Monoclonal
Clone
N253/32 (Formerly sold as S253-32)
Conjugation
APC
Field of Research
Cardiovascular Research
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
270kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Notch1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_032740.3
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
18128

Related Products

CatalogName
GTR18530509Notch1 Rabbit Polyclonal Antibody (APC)
GTR17814074Notch1 Rabbit Polyclonal Antibody (APC)
GTR18692684-01NOTCH1 Human Monoclonal Antibody (APC)
GTR18692683-01NOTCH1 Rat Monoclonal Antibody (APC)
GTR18560638Notch1 Rabbit Polyclonal Antibody (APC)
GTR17816310Activated Notch1 Rabbit Polyclonal Antibody (APC)
GTR18256113Notch1 Rabbit Polyclonal Antibody (APC-Cy7)
GTR18267133Activated Notch1 Rabbit Polyclonal Antibody (APC-Cy7)
GTR17857331Notch1 Antibody
GTR17946202-01NOTCH1 Antibody

Alternative Products

CatalogName
E55A08535Human NOTCH1 Antibody , APC
E55A08536Mouse NOTCH1 Antibody , APC
bs-1335R-APC-TRNotch1 Polyclonal Antibody, APC Conjugated
bsm-60871R-APCNotch1 Recombinant Antibody, APC Conjugated
A00033-2-APCAnti-Notch1 Antibody Picoband® (APC Conjugate)
bs-20252R-APCActivated Notch1 Polyclonal Antibody, APC Conjugated
PA1215-APCAnti-Notch1 Antibody Picoband®, APC Conjugate
FME48313Anti-Mouse NOTCH1 Antibody (SAA0270), APC
MBS1584247-01Anti-Human NOTCH1 Antibody (SAA0131), APC
bsm-60871R-APC-Cy7Notch1 Recombinant Antibody, APC-Cy7 Conjugated

Popular Products