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Brevican Antibody (RPE)

CAT: 0013-GTR18028964Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028964Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Brevican (RPE) . Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE..
Product Name Alternative
Brevican, BCAN, BEHAB, CSPG7, Brain-enriched hyaluronan-binding protein, Brevican core protein, Brevican core protein isoform 1, Brevican core protein isoform 2, Brevican proteoglycan, Chondroitin sulfate proteoglycan 7, Chondroitin sulfate proteoglycan BEHAB, MGC13038
UniProt
P55068
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 219-655 of rat Brevican
Target
Brevican
Clonality
Monoclonal
Clone
N294A/6 (Formerly sold as S294A-6)
Conjugation
RPE
Field of Research
Metabolism Research
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
140kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Brevican in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_001028837.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2B
Entrez
25393

UniProtKB · P55068

Brevican core protein

PGCB_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P55068
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Bcan
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q62860, Q63040, Q63513
Protein keywords

Coding sequence diversity

Alternative splicing

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoproteinGPI-anchorLipoproteinPhosphoproteinProteoglycan

Domain

EGF-like domainImmunoglobulin domainRepeatSignalSushi

Cellular component

Extracellular matrixMembraneSecreted

Ligand

Hyaluronic acidLectin

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