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Batoclimab

CAT: 0804-HY-P99009-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99009-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease[1][2].
CAS Number
2187430-05-1
Product Name Alternative
RVT-1401; HBM9161; IMVT-1401
UNSPSC
12352203
Target
Fc Receptor (FcR)
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/batoclimab.html
Purity
99.89
Solubility
H2O
Smiles
[Batoclimab]
Molecular Weight
(143.43 kDa)
References & Citations
[1]Yan C, et, al. Therapeutic Effects of Batoclimab in Chinese Patients with Generalized Myasthenia Gravis: A Double-Blinded, Randomized, Placebo-Controlled Phase II Study. Neurol Ther. 2022 Apr 12. |[2]Kahaly GJ, et al. Proof-of-concept and Randomized, Placebo-controlled Trials of an FcRn Inhibitor, Batoclimab, for Thyroid Eye Disease. J Clin Endocrinol Metab. 2023 Nov 17;108 (12) :3122-3134.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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