MPTP (hydrochloride)

MPTP (hydrochloride)

• CAS Number: 23007-85-4
• UNSPSC Description: MPTP hydrochloride is a brain penetrant dopamine neurotoxin. MPTP hydrochloride can be used to induces Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. MPTP hydrochloride has been verified by MCE with professional biological experiments.
• Target Antigen: Apoptosis; Dopamine Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;GPCR/G Protein;Neuronal Signaling
• Applications: Cancer-programmed cell death
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/MPTP-hydrochloride.html
• Solubility: DMSO : 12 mg/mL (ultrasonic;warming)|H2O : ≥ 100 mg/mL
• Smiles: CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl
• Molecular Weight: 209.72
• References & Citations: [1]Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12.|[2]Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.|[3]Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180.|[4]Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc. 2007;2(1):141-51.|[5]Rabaneda-Lombarte N, et al. The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease. J Neuroinflammation. 2021 Apr 6;18(1):88. |[6]Lee, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019 Jan;26(2):213-228.|[7]Zhang QS, et al. Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38(10):1317-1328.|[8]Hammock BD, et al., A sheep model for MPTP induced Parkinson-like symptoms. Life Sci. 1989;45(17):1601-8.AfricArXiv Preprints. 2019 Aug.|Antioxidants (Basel). 2023 Nov 13, 12(11), 1999.|Biochem Biophys Res Commun. 2020 Jun 11;526(4):1013-1020.|Bioelectrochemistry. 2020 Aug;134:107532.|bioRxiv. 2023 Jun 26.|Brain Res Bull. 2024 May 31:110989.|Brain Res. 2016 Jul 1;1642:546-552.|Brain Res. 2019 Jul 15;1715:203-212.|Brain Res. 2020 Jan 1;1726:146493.|Brain Res. 2020 Nov 1;1746:147023.|Brain Res. 2019 Oct 15;1721:146334.|Cell Death Dis. 2021 Feb 15;12(2):181.|Cell Death Dis. 2019 Dec 16;10(12):952. |Cell Death Discov. 2022 May 20;8(1):267.|Charles University. 2024 Jan 29.|Chem Eng J. 2024 Sep 20.|CNS Neurosci Ther. 2023 Aug 11.|Exp Neurol. 2024 Dec:382:114958.|Exp Neurol. 2024 Nov 3:115040.|Exp Neurol. 2024 Oct 13:115001.|Front Aging Neurosci. 2023 Jan 25.|Heliyon. 2020 Jul 11;6(7):e04425.|Heliyon. 2024 Oct 1;10(21):e38822.|IBRO Neurosci Rep. 27 November 2021.|Int J Mol Sci. 2024 Nov 27;25(23):12733.|Int J Pharm. 2020 Mar 15;577:119053.|J Ethnopharmacol. 2024 May 10:325:117857.|J Integr Neurosci. 2024 Feb 4;23(2):29.|J Med Chem. 2023 Aug 31.|J Nanobiotechnology. 2024 Sep 14;22(1):567.|J Neuroinflammation. 2024 Apr 12;21(1):92.|Microchemical Journal. 2024 Nov.|Neurosci Lett. 2021 Jan 10;741:135493.|Neurotox Res. 2020 Jun;38(1):27-37.|Neurotox Res. 2023 Jan 27.|Pharmaceutics. 2022, 14(8), 1731.|Pharmacol Biochem Behav. 2019 Feb;177:1-11.|Res Sq. 2024 Sep 08.|Research Square Preprint. 2021 Jun.|Research Square Preprint. 2024 Apr 17.|Signal Transduct Target Ther. 2021 Feb 24;6(1):77.|Toxicol Sci. 2020 Oct 1;177(2):506-520.|University of Szeged. Department of Neurology Faculty of Medicine. 2020 Dec.|Fitoterapia. 2024 Mar 11:105908.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported