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LAMP1 Antibody (APC)

CAT: 0013-GTR18028498Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028498Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to LAMP1 (APC) . Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology. They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane. Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI) . If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome. This stimulation has also been shown to have an associated release of histamine, leukotriene C and prostaglandin D, which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells. They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation..
Product Name Alternative
LAMP1, Lysosome-associated membrane glycoprotein 1, CD107a, CD107, LAMPA, LGP120, IgpA, CD107 antigen-like family member A, 120 kDa lysosomal membrane glycoprotein, Lamp-1
UniProt
P14562
Reactivity
Hamster, Human, Mouse, Rat
Immunogen
Rat liver lysosomal membrane preparations
Target
LAMP1
Clonality
Monoclonal
Clone
Ly1C6
Conjugation
APC
Field of Research
Immunology & Inflammation
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:1000)
Molecular Weight
120kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of LAMP1 in rat liver miscrosome by ECL immunoblot analysis.
Tested Applications
ICC, IF, IP, WB
NCBI Accession Number
NP_036989.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
25328

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