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Ripasudil hydrochloride dihydrate

CAT: 0026-B2984-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2984-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including retraction, cell rounding and reduced actin bundles of cultured trabecular meshwork (TM) cells. It significantly reduces transendothelial electrical resistance (TEER) and increases FITC-dextran permeability in Schlemm’s canal endothelial (SCE) cell monolayers at a concentration of 5 μM. A 0.4% ophthalmic solution significantly lowers intraocular pressure (IOP) in rabbits and monkeys. It was the first ophthalmic solution developed for the treatment of glaucoma and ocular hypertension in Japan.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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