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KRAS ligand 4

CAT: 0804-HY-161236Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161236Size:1 Each
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Description
KRAS ligand 4 (compound 2) is a bifunctional molecular glue degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations[1].
UNSPSC
12352005
Target
Molecular Glues; Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-ligand-4.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC([C@@H](C)NC2=NC(Cl)=NC3=C2CN(C(C4(OC)CCN(C(C)=O)CC4)=O)C3)=CC(N)=C1
Molecular Formula
C24H28ClF3N6O3
Molecular Weight
540.97
References & Citations
[1]Begovich K, et al. Cereblon-Based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Jan 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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