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Spinoxin

CAT: 0804-HY-P5931Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5931Size:100 µg
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Description
Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers[1].
CAS Number
752984-66-0
Product Name Alternative
Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/spinoxin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3(C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@]4(C(=O)N[C@@H](CCCCN)C(=O)N[C@@]5(C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)NCC(=O)N[C@H](C(N)=O)CSSC[C@@]1(NC(=O)CNC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@](CSSC5)(NC(=O)[C@]7(N(C(=O)[C@H](CO)NC(=O)[C@H](CC8=CC=C(O)C=C8)NC(=O)[C@](CSSC4)(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCNC(=N)N)=O)CSSC3)[H])CCC7)[H])[H])[H])[H])[H])[H])[H])[H])[H]
Molecular Formula
C147H236N48O46S9
Molecular Weight
3700.33
References & Citations
[1]Steve Peigneur, et al. Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning. Biochemistry. 2016 May 31;55 (21) :2927-35.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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