AP2M1 (phospho-Thr156) rabbit pAb

AP2M1 (phospho-Thr156) rabbit pAb

• Description: This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015],
• Synonyms: AP-2 complex subunit mu (AP-2 mu chain) (Adapter-related protein complex 2 mu subunit) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Clathrin assembly protein complex 2 medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
• Gene ID: 1173
• UniProt: Q96CW1
• Cellular Locus: Cell membrane. Membrane, coated pit ; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized phosho peptide around human AP2M1 (Thr156)
• Clonality: Polyclonal
• Validated Applications: WB
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000
• Molecular Weight: 47kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.