S100 rabbit pAb

• Background:

  S100 calcium binding protein A1 (S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

• Description:

  S100 calcium binding protein A1 (S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],

• Synonyms:

  Protein S100-A1 (S-100 protein alpha chain;S-100 protein subunit alpha;S100 calcium-binding protein A1)

• Gene ID:

  6271

• UniProt:

  P23297

• Cellular Locus:

  Cytoplasm. Sarcoplasmic reticulum. Mitochondrion.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Recombinant Protein of S100

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF

• Validated Applications:

  WB, IHC, IF

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  15kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  15 kD

• Subcellular Location:

  Cytoplasm . Sarcoplasmic reticulum . Mitochondrion .

• Other Product Names:

  Protein S100-A1 (S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1)

• Gene ID (Human):

  6271

• SwissProt (Human):

  P23297