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S100 rabbit pAb

CAT: 0855-ES20636-01Size: 50 µLDry Ice: NoHazardous: No
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Background
S100 calcium binding protein A1 (S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Description
S100 calcium binding protein A1 (S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],
UniProt
P23297
Swiss Prot
P23297
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant Protein of S100
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
15kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
15kD
Fragment
IgG
Subcellular Location
Cytoplasm . Sarcoplasmic reticulum . Mitochondrion .
Other Product Names
Protein S100-A1 (S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1)
Gene ID (Human)
6271

UniProtKB · P23297

Protein S100-A1

S10A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23297
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
S100A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R5D9, Q5T7Y3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

CytoplasmMitochondrionSarcoplasmic reticulum

PTM

GlutathionylationS-nitrosylation

Domain

Repeat