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MMP9 Antibody (APC)

CAT: 0013-GTR18028819Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028819Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to MMP9 (APC) . MMP9, otherwise known as matrix metalloproteinase 9, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes like arthritis and metastasis. Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4) . MMP activity correlates with cancer development. One mechanism of MMP regulation is transcriptional. Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein..
Product Name Alternative
MMP9, MMP-9, Matrix metalloproteinase 9, CLG4B, 82kDa matrix metalloproteinase-9, Collagenease type 4 beta, GELB, Macrophage gelatinase, MANDP2, Type V collagenase, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B
UniProt
P50282
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1-708 (full length) of rat MMP9
Target
MMP9
Clonality
Monoclonal
Clone
L51/82 (Formerly sold as S51-82)
Conjugation
APC
Field of Research
Cancer Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
82kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of MMP9 in 20 μg of COS-1 cells (lysate) transfected with human MMP9 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
FC, ICC, IF, IHC, IP, WB
NCBI Accession Number
NP_112317.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2a
Entrez
81687

UniProtKB · P50282

Matrix metalloproteinase-9

MMP9_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P50282
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mmp9
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
MMP-9
EC number
3.4.24.35
Processing
Precursor
Secondary accessions
—
Protein keywords

Ligand

CalciumMetal-bindingZinc

Biological process

Collagen degradation

PTM

Disulfide bondGlycoproteinZymogen

Cellular component

Extracellular matrixSecreted

Molecular function

HydrolaseMetalloproteaseProtease

Technical term

Reference proteome

Domain

RepeatSignal

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