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Milameline (hydroiodide)

CAT: 0804-HY-107650A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107650A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Milameline (CI 979; RU35926) hydroiodide is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydroiodide has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydroiodide has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydroiodide produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine. Milameline hydroiodide can be used for the study of Alzheimer’s Disease[1].
Product Name Alternative
CI 979 (hydroiodide) ; RU 35926 (hydroiodide)
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/milameline-hydroiodide.html
Purity
96.25
Smiles
CO/N=C/C1=CCCN(C)C1.I
Molecular Formula
C8H15IN2O
Molecular Weight
282.12
References & Citations
[1]Heidrich, A., and M. Rösler. "Milameline hydrochloride: nonselective, partial muscarinic receptor agonist for the treatment of Alzheimer's disease?." CNS Drug Reviews (1999) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR3; mAChR4

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