Pdcd-1 rabbit pAb

• Background :

  This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

• Description :

  This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],

• UniProt :

  Q15116

• Swiss Prot :

  Q15116

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human Pdcd-1 AA range: 80-130

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein.

• Other Product Names :

  Programmed cell death protein 1 (Protein PD-1; hPD-1; CD antigen CD279)

• Gene ID (Human) :

  5133