Smad2/3-IN-1

• UNSPSC Description:

  Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively[1].

• Target Antigen:

  Interleukin Related; STAT; TGF-beta/Smad

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/smad2-3-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(C(/C(C)=C/C[C@H](O)[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1

• Molecular Weight:

  368.81

• References & Citations:

  [1]Seipp K, et al., Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione. J Nat Prod. 2024 Mar 31.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported