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KIR3.2 rabbit pAb

CAT: 0855-ES15302-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15302-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
Description
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015],
UniProt
P48051
Swiss Prot
P48051
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human KIR3.2
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, WB 1:500-2000
Molecular Weight
48kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
48kD
Fragment
IgG
Subcellular Location
Membrane; Multi-pass membrane protein.
Other Product Names
G protein-activated inward rectifier potassium channel 2 (GIRK-2; BIR1; Inward rectifier K (+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6)
Gene ID (Human)
3763

UniProtKB · P48051

G protein-activated inward rectifier potassium channel 2

KCNJ6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48051
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KCNJ6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GIRK-2
EC number
—
Processing
—
Secondary accessions
Q3MJ74, Q53WW6
Protein keywords

Disease

Congenital generalized lipodystrophyDisease variantIntellectual disability

Molecular function

Ion channelVoltage-gated channel

Biological process

Ion transportPotassium transportTransport

Cellular component

Membrane

PTM

Phosphoprotein

Ligand

Potassium

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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