CD68 antibody

• Background:

  This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

• Synonyms:

  Macrosialin|Gp110|CD68

• Gene ID:

  968

• UniProt:

  P34810

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  CD68 molecule

• Target:

  CD68

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC, WB

• Field of Research:

  Neuroscience, Stem Cells, Immunology, Cancer

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  31 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC, WB

• Immunogen Sequence:

  131-240aa