Umifenovir-d6 (hydrochloride)

Umifenovir-d6 (hydrochloride)

• CAS Number: 2928218-29-3
• UNSPSC Description: Umifenovir-d6 (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].
• Target Antigen: Influenza Virus; Isotope-Labeled Compounds; SARS-CoV
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Others
• Field of Research: Infection
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming)
• Smiles: O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(O)C(Br)=C3)OCC.[H]Cl
• Molecular Weight: 519.91
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005.|[3]Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083.|[4]Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported