Umifenovir (hydrochloride)

Umifenovir (hydrochloride)

• CAS Number: 131707-23-8
• UNSPSC Description: Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].
• Target Antigen: Influenza Virus; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/Arbidol-hydrochloride.html
• Solubility: DMSO : 25 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC.[H]Cl
• Molecular Weight: 513.88
• References & Citations: [1]Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005.|[2]Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083.|[3]Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2.bioRxiv. 2020 Mar.|Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.|mBio. 2021 Feb 22;13(1):e0304421.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Signal Transduct Target Ther. 2021 Apr 24;6(1):165.|Viruses. 2021, 13(8).|Viruses. 2019 Jul 20;11(7):665. |SSRN. 2024 Jan 26.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched