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Meldonium

CAT: 0804-HY-B1836-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1836-03Size:100 mg
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Description
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2) . Meldonium exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].
CAS Number
76144-81-5
Product Name Alternative
MET-88; Quaterin
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/meldonium.html
Purity
99.89
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
C[N+](C)(C)NCCC([O-])=O
Molecular Formula
C6H14N2O2
Molecular Weight
146.19
Precautions
H315, H319, H335
References & Citations
[1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113 (Pt B) :771-780.|[2]Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470 (2) :100-5.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
J Anim Sci. 2022 Apr 1;100 (4) :skac069.|Nat Commun. 2025 Feb 11;16 (1) :1543.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.

Chemical Information

Meldonium

Meldonium is an ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes. It has a role as an EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor, a neuroprotective agent and a cardioprotective agent.

CAS Number76144-81-5
PubChem CID123868
IUPAC Name3-[(trimethylazaniumyl)amino]propanoate
Molecular FormulaC6H14N2O2
Molecular Weight146.19
XLogP-2.1
Topological Polar Surface Area52.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count10
Formal Charge0
Complexity112
SMILES
C[N+](C)(C)NCCC(=O)[O-]
InChI
InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
InChIKey
PVBQYTCFVWZSJK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Meldonium
CAS: 76144-81-5
CID: 123868
Formula: C6H14N2O2
MW: 146.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight146.19
XLogP3-2.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass146.105527694
Monoisotopic Mass146.105527694
Topological Polar Surface Area52.2 Ų
Heavy Atom Count10
Formal Charge0
Complexity112
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BT164669Meldonium dihydrate - Bio-X TM

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