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OPC-163493

CAT: 0804-HY-134769-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134769-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease[1][2].
CAS Number
1644467-84-4
UNSPSC
12352005
Target
Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/opc-163493.html
Purity
99.34
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2=C(C)SC(C3=CC=C(C(F)(F)F)C=C3)=N2)N=NN1
Molecular Formula
C14H8F3N5S
Molecular Weight
335.31
References & Citations
[1]Kanemoto N, et al. Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler. Nat Commun. 2019 May 15;10 (1) :2172.|[2]Inoue Y, et al. Preclinical safety profile of a liver-localized mitochondrial uncoupler: OPC-163493. EXCLI J. 2022 Jan 11;21:213-235.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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