OPC-4392

CAT: 0804-HY-106781Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106781Size:1 Each
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Description
OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480) -induced dopamine accumulation, inhibits Apomorphine (HY-12723) -induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent[1][2].
CAS Number
[111073-34-8]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC(C(C)=CC=C1)=C1N(CC2)CCN2CCCOC3=CC=C(C=CC4=O)C(N4)=C3
Molecular Formula
C24H29N3O2
Molecular Weight
391.51
References & Citations
[1]Yasuda Y, et al. 7-[3- (4-[2,3-Dimethylphenyl]piperazinyl) propoxy]-2 (1H) -quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42 (20) :1941-54.|[2]Murasaki M, et al. Phase 1 study of a new antipsychotic drug, OPC-4392. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12 (5) :793-802.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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