Tibolone-d5

• Description:

  Tibolone-d5 is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2].

• UNSPSC:

  12352211

• Target:

  Androgen Receptor; Estrogen Receptor/ERR; Isotope-Labeled Compounds; Progesterone Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Endocrinology

• Smiles:

  C[C@]([C@@](O)(C([2H])([2H])C1)C#C)(CC[C@]2([H])C3=C(CC(CC3)=O)C4)[C@]1([H])[C@]2([H])[C@@H]4C([2H])([2H])[2H]

• Molecular Formula:

  C21H23D5O2

• Molecular Weight:

  317.48

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31 (7) :655-668.|[3]Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported