Tibolone

• Description :

  Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Androgen Receptor; Estrogen Receptor/ERR; Progesterone Receptor

• Type :

  Natural Products

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/tibolone.html

• Concentration :

  10mM

• Purity :

  99.9

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](O)(CC3)C#C)(CC[C@]2([H])C4=C(CC(CC4)=O)C1)C

• Molecular Formula :

  C21H28O2

• Molecular Weight :

  312.45

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31 (7) :655-668.|[2]Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [5630-53-5]