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(S) -Tenofovir

CAT: 0804-HY-W074930-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W074930-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Tenofovir ((S) -GS 1278) is the less active S-enantiomer of Tenofovir. Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV) [1].
CAS Number
147127-19-3
Product Name Alternative
(S) -GS 1278; (S) -PMPA; (S) -TDF
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HBV; HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/s-tenofovir.html
Purity
99.99
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OP(O)(CO[C@@H](C)CN1C=NC2=C(N)N=CN=C12)=O
Molecular Formula
C9H14N5O4P
Molecular Weight
287.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18 (3) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-Pmpa
CAS Number147127-19-3
PubChem CID122767
IUPAC Name[(2S)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
Molecular FormulaC9H14N5O4P
Molecular Weight287.21
XLogP-1.6
Topological Polar Surface Area136
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count19
Formal Charge0
Complexity354
SMILES
C[C@@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
InChI
InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m0/s1
InChIKey
SGOIRFVFHAKUTI-LURJTMIESA-N
Chemical Structure
2D Structure
2D structure of (S)-Pmpa
CAS: 147127-19-3
CID: 122767
Formula: C9H14N5O4P
MW: 287.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.21
XLogP3-1.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass287.07834094
Monoisotopic Mass287.07834094
Topological Polar Surface Area136 Ų
Heavy Atom Count19
Formal Charge0
Complexity354
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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