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HMBPP (lithium)

CAT: 0804-HY-134891Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134891Size:1 mg
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Description
HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].
CAS Number
[396726-03-7]
Product Name Alternative
(E) -4-Hydroxy-3-methyl-but-2-enyl diphosphate (lithium)
UNSPSC
12352211
Hazard Statement
H302
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hmbpp.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=P(OP(O[Li])(O[Li])=O)(O[Li])OC/C=C(C)/CO
Molecular Formula
C5H9Li3O8P2
Molecular Weight
279.89
Precautions
H302
References & Citations
[1]Hintz M, et al., Identification of (E) -4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509 (2) :317-22.|[2]Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4 (1) :1161.|[3]Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153 (3) :403-415. |[4]Nguyen K, et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31 (11) :4697-4706. |[5]Huang D, et al. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions. Proc Natl Acad Sci U S A. 2009 May 5;106 (18) :7553-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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