HMBPP (lithium)

• Description :

  HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].

• Product Name Alternative :

  (E) -4-Hydroxy-3-methyl-but-2-enyl diphosphate (lithium)

• UNSPSC :

  12352211

• Hazard Statement :

  H302

• Target :

  Nuclear Factor of activated T Cells (NFAT)

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/hmbpp.html

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(OP(O[Li])(O[Li])=O)(O[Li])OC/C=C(C)/CO

• Molecular Formula :

  C5H9Li3O8P2

• Molecular Weight :

  279.89

• Precautions :

  H302

• References & Citations :

  [1]Hintz M, et al., Identification of (E) -4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509 (2) :317-22.|[2]Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4 (1) :1161.|[3]Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153 (3) :403-415. |[4]Nguyen K, et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31 (11) :4697-4706. |[5]Huang D, et al. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions. Proc Natl Acad Sci U S A. 2009 May 5;106 (18) :7553-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [396726-03-7]