HMBPP (lithium)

• Description:

  HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].

• Product Name Alternative:

  (E) -4-Hydroxy-3-methyl-but-2-enyl diphosphate (lithium)

• UNSPSC:

  12352211

• Hazard Statement:

  H302

• Target:

  Nuclear Factor of activated T Cells (NFAT)

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hmbpp.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P (OP (O[Li]) (O[Li]) =O) (O[Li]) OC/C=C (C) /CO

• Molecular Formula:

  C5H9Li3O8P2

• Molecular Weight:

  279.89

• Precautions:

  H302

• References & Citations:

  [1]Hintz M, et al., Identification of (E) -4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509 (2) :317-22.|[2]Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4 (1) :1161.|[3]Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153 (3) :403-415. |[4]Nguyen K, et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31 (11) :4697-4706. |[5]Huang D, et al. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions. Proc Natl Acad Sci U S A. 2009 May 5;106 (18) :7553-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  396726-03-7