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Voreloxin (Hydrochloride)

CAT: 0804-HY-16518-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16518-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
CAS Number
175519-16-1
Product Name Alternative
SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Voreloxin-Hydrochloride.html
Purity
99.58
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O
Molecular Formula
C18H20ClN5O4S
Molecular Weight
437.90
References & Citations
[1]Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16 (9) :1395-402.|[2]Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66 (5) :881-8.|[3]Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96 (3) :393-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Topo II

Chemical Information

Voreloxin Hydrochloride
CAS Number175519-16-1
PubChem CID10343042
IUPAC Name7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid;hydrochloride
Molecular FormulaC18H20ClN5O4S
Molecular Weight437.9
Topological Polar Surface Area136
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity662
SMILES
CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O.Cl
InChI
InChI=1S/C18H19N5O4S.ClH/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18;/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26);1H/t12-,13-;/m0./s1
InChIKey
JJZCCQHWCOXGCL-QNTKWALQSA-N
Chemical Structure
2D Structure
2D structure of Voreloxin Hydrochloride
CAS: 175519-16-1
CID: 10343042
Formula: C18H20ClN5O4S
MW: 437.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight437.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass437.0924530
Monoisotopic Mass437.0924530
Topological Polar Surface Area136 Ų
Heavy Atom Count29
Formal Charge0
Complexity662
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A3925-5Voreloxin Hydrochloride
A15280-10Voreloxin Hydrochloride 10mg
A15280-50Voreloxin Hydrochloride 50mg
A15280-25Voreloxin Hydrochloride 25mg
A15280-5Voreloxin Hydrochloride 5mg
A15280-100Voreloxin Hydrochloride 100mg
A15280-2Voreloxin Hydrochloride 2mg
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A15280-10mM-DVoreloxin Hydrochloride 10mM * 1mL in DMSO
202650Voreloxin

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