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N-Acetyl-D-mannosamine

CAT: 0804-HY-128850-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128850-01Size:100 mg
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Description
N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders[1][2][3][4][5].
CAS Number
3615-17-6
Product Name Alternative
N-Acetylmannosamine; ManNAc
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/n-acetyl-d-mannosamine.html
Purity
99.99
Solubility
H2O : 116.67 mg/mL (ultrasonic)
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
Molecular Formula
C8H15NO6
Molecular Weight
221.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511 (1-3) :97-101.|[2]Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12 (9) :764-778.|[3]Peng J, et al. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. 2019 Dec 10;140 (24) :2005-2018.|[4]Niethamer TK, et al. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Mol Genet Metab. 2012 Dec;107 (4) :748-55.|[5]Taniguchi S, et al. Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Neurosci Lett. 2015 Jun 26;598:41-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Human Endogenous Metabolite

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