Moxidectin (Standard)

Moxidectin (Standard)

• CAS Number: 113507-06-5
• UNSPSC Description: Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk[1][2][3].
• Target Antigen: Antibiotic; BCRP; Parasite; P-glycoprotein
• Type: Reference Standards
• Related Pathways: Anti-infection;Membrane Transporter/Ion Channel
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/moxidectin-standard.html
• Solubility: H2O : < 0.1 mg/mL
• Smiles: C/C([C@H]([C@H](/C1=N/OC)C)O[C@]2(C1)C[C@](OC([C@@](C=C(C)[C@@H](O)[C@@]3([H])OC/C4=C\C=C\[C@H](C)C5)([H])[C@@]34O)=O)([H])C[C@](C/C=C5\C)([H])O2)=C\C(C)C
• Molecular Weight: 639.82
• References & Citations: [1]Moxidectin, From Wikipedia|[2]Kiki-Mvouaka S, et al. Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice. Drug Metab Dispos. 2010 Apr;38(4):573-80.|[3]Perez M, et al. In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 2009 Jun 15;180(1):106-12.
• Shipping Conditions: Room temperature
• Clinical Information: Launched