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Moxidectin (Standard)

CAT: 0804-HY-B0777R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0777R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk[1][2][3].
CAS Number
113507-06-5
Product Name Alternative
CL301423 (Standard)
UNSPSC
12352005
Hazard Statement
H301-H400
Target
Antibiotic; BCRP; Parasite; P-glycoprotein; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/moxidectin-standard.html
Solubility
H2O : < 0.1 mg/mL
Smiles
C/C([C@H]([C@H](/C1=N/OC)C)O[C@]2(C1)C[C@](OC([C@@](C=C(C)[C@@H](O)[C@@]3([H])OC/C4=C\C=C\[C@H](C)C5)([H])[C@@]34O)=O)([H])C[C@](C/C=C5\C)([H])O2)=C\C(C)C
Molecular Formula
C37H53NO8
Molecular Weight
639.82
Precautions
P264-P270-P273-P330-P391-P405-P501
References & Citations
[1]Moxidectin, From Wikipedia|[2]Kiki-Mvouaka S, et al. Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice. Drug Metab Dispos. 2010 Apr;38 (4) :573-80.|[3]Perez M, et al. In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 2009 Jun 15;180 (1) :106-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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