Sheep anti Human HER2/neu

Sheep anti Human HER2/neu

• Background: c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein.
• Synonyms: p185erbB2, MLN 19, CD340, c-ErbB-2
• CAS Number: 9007-83-4
• UniProt: P04626
• Host: Sheep
• Species Reactivity: Human
• Isotype: IgG
• Conjugation: Unconjugated
• Type: Polyclonal Antibody
• Applications: WB
• Field of Research: Signal Transduction
• Purification Method: Ammonium Sulfate Precipitation
• Assay Principle: Antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.
• Stability: See expiration date on vial
• Concentration: See vial for Concentration
• Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
• Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
• References & Citations: 1. Stancovski, I et. al. 'Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.' Proc. Natl. Acad. Sci USA, 1991, 88(19):8691-5. 2. Hurwitz E et. al. 'Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.' Proc. Natl. Acad. Sci USA, 1995, 92(8):3353-7.
• Shipping Conditions: Ambient Temperature, freeze upon arrival
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
• Functional Analysis: WB