Lenalidomide-Pip-butyn

Lenalidomide-Pip-butyn

• CAS Number: 2497589-76-9
• UNSPSC Description: Lenalidomide-Pip-butyn is Lenalidomide (HY-A0003)-based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360)[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lenalidomide-pip-butyn.html
• Smiles: O=C(C(CC1)N(C2=O)CC3=C2C=CC=C3C#CCCC4CCNCC4)NC1=O
• Molecular Weight: 379.45
• References & Citations: [1]Renqi Xu, et al. Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. J Med Chem. 2024 Nov 28;67(22):20495-20513.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported