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Lenalidomide-Pip-butyn

CAT: 0804-HY-169362Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169362Size:1 Each
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Description
Lenalidomide-Pip-butyn is Lenalidomide -based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360).
CAS Number
2497589-76-9
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-pip-butyn.html
Smiles
O=C(C(CC1)N(C2=O)CC3=C2C=CC=C3C#CCCC4CCNCC4)NC1=O
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]Renqi Xu, et al. Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. J Med Chem. 2024 Nov 28;67 (22) :20495-20513.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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