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CB2 receptor agonist 9

CAT: 0804-HY-168734Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168734Size:1 Each
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Description
CB2 receptor agonist 9 (Compound 33) is an orally active agonist for cannabinoid receptor 2 (CB2 receptor) with an EC50 of 16.2 nM. CB2 receptor agonist 9 inhibits the expression of TNF-α, IL-1β and IL-6, exhibits anti-inflammatory efficacy in DDS -induced mouse acute colitis model[1].
CAS Number
2374894-21-8
UNSPSC
12352211
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cb2-receptor-agonist-9.html
Smiles
CCCCN1N=C(C=C1C2=CC=CS2)C(NC(C)(CO)C)=O
Molecular Formula
C16H23N3O2S
Molecular Weight
321.44
References & Citations
[1]Jiang BE, et al., Design, synthesis, and biological evaluations of 5-aryl-pyrazole-3-carboxamide derivatives as selective CB2 receptor agonists for the treatment of colitis. Eur J Med Chem. 2024 Dec 2;283:117117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2

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